MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc
نویسندگان
چکیده
منابع مشابه
MicroRNA-506 suppresses growth and metastasis of oral squamous cell carcinoma via targeting GATA6.
Oral squamous cell carcinoma (OSCC) remains the main cause of cancer mortality, accounts for 90% of oral cancers. Increasing evidence reveals that aberrant expression of microRNA contributes to the development and progression of OSCC, but the roles of microRNA-506 (miR-506) in OSCC remain elusive. Here, we found that the expression of miR-506 was decreased in 21 OSCC tissues and SCC-4 and SCC-9...
متن کاملMicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma.
We investigated the functional effects of microRNA-34a (miR-34a) on c-Myc transcriptional complexes in renal cell carcinoma. miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region, which was revealed by luciferase reporter assays. miR-34a was also found to repress RhoA expression by suppressing the c-Myc-Skp2-Miz1 transcriptional complex ...
متن کاملMicroRNA-433 inhibits oral squamous cell carcinoma cells by targeting FAK
We investigated the involvement of microRNA-433 (miR-433) in the proliferation, migration, and invasiveness of oral squamous cell carcinoma (OSCC). Totally 108 OSCC tissues and adjacent normal tissues from patients with OSCC were collected. Also, transplanted tumor formation experiment in nude mice was conducted to verify the effect of miR-433 and FAK on subcutaneous transplanted tumor. The CD4...
متن کاملCircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance
Objective(s): Circular RNAs (circRNAs), a new class of non-coding RNAs, have emerged as important regulators during tumorigenesis. However, the functions of circRNAs have not been completely clarified in the progression of cancers. In our study, a novel circRNA hsa_circ_0109291 was investigated in oral squamous cell carcinoma (OSCC) tissues and cell lines. Materials and Methods: The expression ...
متن کاملDownregulation of microRNA-155 accelerates cell growth and invasion by targeting c-myc in human gastric carcinoma cells.
MicroRNAs (miRNAs) are a recently discovered class of small non-coding RNAs that regulate gene expression. miRNAs can contribute to cancer development and progression and are differentially expressed in normal tissue and cancer. In the present study, our aim was to investigate the expression of miR-155 in gastric cancer and to explore the mechanisms by which it influences gastric cancer cells. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncology Letters
سال: 2018
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2018.8967